Understanding how DNA-PKcs affects DNA repair and cancer development
The role of DNA-PKcs in DNA repair, lymphocyte development, RNA metabolism and tumor suppression
This study is looking at how a specific protein helps fix DNA and supports immune cell development, which could lead to new treatments for blood cancers like lymphoma and leukemia, ultimately aiming to improve care for patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Columbia University Health Sciences NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-11064312 on NIH RePORTER |
What this research studies
This research investigates the role of DNA-dependent protein kinase (DNA-PKcs) in repairing DNA, developing immune cells, and its involvement in cancer. The project employs genetic and cell biology techniques to explore how DNA-PKcs interacts with RNA and DNA, particularly in the context of lymphoma and leukemia. By analyzing the effects of depleting a protein called KU on RNA metabolism in human cells, the research aims to uncover critical insights that could lead to new cancer therapies. Patients may benefit from advancements in understanding how DNA repair mechanisms can be targeted in cancer treatment.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research are individuals diagnosed with lymphoma or leukemia.
Not a fit: Patients with cancers unrelated to DNA repair mechanisms may not receive benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved cancer treatments by targeting DNA repair mechanisms.
How similar studies have performed: Previous research has shown promising results in targeting DNA repair pathways for cancer treatment, indicating potential success for this approach.
Where this research is happening
New York, United States
- Columbia University Health Sciences — New York, United States (Active)
Researchers
- Principal investigator: Zha, Shan — Columbia University Health Sciences
- Study coordinator: Zha, Shan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.