Understanding how DNA organization affects gene expression
Towards fully reconstituting mammalian transcription in a test tube
['FUNDING_OTHER'] · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · NIH-11014616
This study is looking at how the way DNA is organized in our cells affects which genes are turned on or off, which could help us understand diseases like cancer and other conditions related to gene expression.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (nih funded) |
| Locations | 1 site (CAMBRIDGE, UNITED STATES) |
| Trial ID | NIH-11014616 on ClinicalTrials.gov |
What this research studies
This research investigates the intricate relationship between DNA organization within the cell nucleus and the process of gene expression. By reconstituting transcription reactions in a controlled laboratory setting, the researchers aim to uncover how the physical arrangement of DNA and associated proteins influences which genes are activated. Utilizing advanced techniques such as high throughput biochemical assays and cryo-electron microscopy, the study seeks to provide insights into the mechanisms that govern cell function and specificity. This knowledge could be pivotal in understanding diseases linked to gene expression, such as cancer and developmental disorders.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals affected by conditions related to gene expression, such as certain cancers or developmental delays.
Not a fit: Patients with conditions unrelated to gene expression or those not affected by genetic disorders may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for treating diseases caused by improper gene expression.
How similar studies have performed: Previous research has shown promising results in understanding gene expression mechanisms, but this approach of reconstituting transcription in vitro is relatively novel.
Where this research is happening
CAMBRIDGE, UNITED STATES
- MASSACHUSETTS INSTITUTE OF TECHNOLOGY — CAMBRIDGE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: VOS, SEYCHELLE MONQIUE — MASSACHUSETTS INSTITUTE OF TECHNOLOGY
- Study coordinator: VOS, SEYCHELLE MONQIUE
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Cancers