Understanding how DNA modifications are maintained across generations
Official title: Identifying mechanisms underpinning epigenetic homeostasis
Funded at University of California Berkeley · NIH-11123426 · Data updated 2026-11-12
This study looks at how certain enzymes in plants help control DNA markings that affect how genes work, which could help us understand more about aging and diseases like cancer that also involve these processes.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Berkeley NIH-funded |
| Lab location | 1 site (Berkeley, United States) |
| Project start | July 1, 2024 |
| Project end | May 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $401,250 |
| NIH project number | 5R35GM154941-02 |
| Project ID | NIH-11123426 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit from this research include individuals interested in the genetic factors associated with aging and cancer.
✕Less likely to help
Patients with conditions unrelated to DNA methylation or those not affected by age-related genetic changes may not receive benefits from this research.
What this research studies
This research investigates the mechanisms that control DNA methylation, a crucial process for regulating gene expression and maintaining genetic stability. By using the plant model Arabidopsis, the study aims to uncover how enzymes that add or remove DNA methylation marks work together to ensure accurate inheritance of these modifications over time. The research will involve detailed analysis of how these enzymes are regulated during the cell cycle and the identification of additional factors that influence their activity. Patients may benefit from insights gained into the role of DNA methylation in aging and diseases like cancer.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating age-related diseases and cancers by targeting the mechanisms of DNA methylation.
How similar studies have gone: Previous research has shown promising results in understanding DNA methylation mechanisms, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of California Berkeley
Berkeley, United States Active
Researchers
- Principal investigator: Williams, Ben — University of California Berkeley
- Study coordinator: Williams, Ben
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.