Understanding how DNA modifications are maintained across generations
Identifying mechanisms underpinning epigenetic homeostasis
['FUNDING_OTHER'] · UNIVERSITY OF CALIFORNIA BERKELEY · NIH-11123426
This study looks at how certain enzymes in plants help control DNA markings that affect how genes work, which could help us understand more about aging and diseases like cancer that also involve these processes.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CALIFORNIA BERKELEY (nih funded) |
| Locations | 1 site (BERKELEY, UNITED STATES) |
| Trial ID | NIH-11123426 on ClinicalTrials.gov |
What this research studies
This research investigates the mechanisms that control DNA methylation, a crucial process for regulating gene expression and maintaining genetic stability. By using the plant model Arabidopsis, the study aims to uncover how enzymes that add or remove DNA methylation marks work together to ensure accurate inheritance of these modifications over time. The research will involve detailed analysis of how these enzymes are regulated during the cell cycle and the identification of additional factors that influence their activity. Patients may benefit from insights gained into the role of DNA methylation in aging and diseases like cancer.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research include individuals interested in the genetic factors associated with aging and cancer.
Not a fit: Patients with conditions unrelated to DNA methylation or those not affected by age-related genetic changes may not receive benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating age-related diseases and cancers by targeting the mechanisms of DNA methylation.
How similar studies have performed: Previous research has shown promising results in understanding DNA methylation mechanisms, suggesting that this approach could yield valuable insights.
Where this research is happening
BERKELEY, UNITED STATES
- UNIVERSITY OF CALIFORNIA BERKELEY — BERKELEY, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: WILLIAMS, BEN — UNIVERSITY OF CALIFORNIA BERKELEY
- Study coordinator: WILLIAMS, BEN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Cancers