Understanding how DNA modifications affect gene expression
Epigenetic regulations of DNA and histone methylation and deMethylation: Structures and Mechanisms
['FUNDING_OTHER'] · UNIVERSITY OF TX MD ANDERSON CAN CTR · NIH-11010081
This study is looking at how tiny changes to our DNA can affect how genes are turned on and off, which could help us understand more about how our bodies work and how we can better manage health conditions related to gene expression.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF TX MD ANDERSON CAN CTR (nih funded) |
| Locations | 1 site (HOUSTON, UNITED STATES) |
| Trial ID | NIH-11010081 on ClinicalTrials.gov |
What this research studies
This research investigates the mechanisms by which epigenetic modifications, specifically DNA and histone methylation and demethylation, influence protein-DNA interactions that control gene expression. By exploring how these modifications affect the binding of transcription factors to DNA, the research aims to uncover the complexities of gene regulation. The approach involves studying the various forms of methylated DNA and their impact on chromatin structure and stability, which could lead to new insights into gene expression control.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with conditions influenced by gene expression, particularly those under 21 years old or adults with relevant genetic disorders.
Not a fit: Patients with conditions unrelated to epigenetic modifications or gene expression may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic targets for diseases linked to gene regulation.
How similar studies have performed: Previous research has shown promising results in understanding epigenetic modifications and their role in gene regulation, indicating that this approach has potential for significant breakthroughs.
Where this research is happening
HOUSTON, UNITED STATES
- UNIVERSITY OF TX MD ANDERSON CAN CTR — HOUSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: CHENG, XIAODONG — UNIVERSITY OF TX MD ANDERSON CAN CTR
- Study coordinator: CHENG, XIAODONG
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.