Understanding how DNA methylation is influenced by histone modifications
Official title: Mechanisms of DNA methylation and its regulation by epigenetic histone modifications
Funded at New York University School of Medicine · NIH-11068252 · Data updated 2026-11-12
This study is looking at how certain changes in our DNA and proteins affect how our genes work, which could help us find better treatments for age-related diseases and cancers, so patients with conditions like cancer and dementia might get improved care in the future.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | New York University School of Medicine NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | May 7, 2025 |
| Project end | May 6, 2027 |
| Funding year | 2025 |
| Award (this year) | $49,538 |
| NIH project number | 1F31CA294844-01A1 |
| Project ID | NIH-11068252 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals at risk for age-related diseases, particularly those with a family history of cancer or dementia.
✕Less likely to help
Patients with no history of age-related diseases or cancers may not receive direct benefits from this research.
What this research studies
This research investigates the relationship between DNA methylation and histone modifications, which are crucial for regulating gene expression. By examining the structure of a key enzyme, DNMT1, in relation to modified nucleosomes, the study aims to uncover the mechanisms that govern DNA methylation. This could lead to the development of more targeted therapies for age-related diseases and cancers linked to abnormal DNA methylation patterns. Patients may benefit from insights that could improve treatment strategies for conditions like cancer and dementia.
Why it matters
Potential benefit: If successful, this research could lead to more effective and targeted treatments for cancers and age-related diseases by improving our understanding of DNA methylation.
How similar studies have gone: Previous research has shown promising results in understanding DNA methylation mechanisms, suggesting that this approach could yield valuable insights.
Where this research is happening
-
New York University School of Medicine
New York, United States Active
Researchers
- Principal investigator: Thomas, Jonathan — New York University School of Medicine
- Study coordinator: Thomas, Jonathan
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.