Understanding how DNA methylation differs between male and female reproductive cells
Official title: Molecular determinants of sex-specific DNA methylation signature acquisition in the mammalian germline
Funded at University of Pennsylvania · NIH-10895484 · Data updated 2026-11-12
This study is exploring how male and female reproductive cells differ in their DNA patterns, which could help us understand fertility issues and developmental problems, making it relevant for anyone interested in reproductive health.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pennsylvania NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project start | September 1, 2023 |
| Project end | August 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $120,020 |
| NIH project number | 5K99HD112543-02 |
| Project ID | NIH-10895484 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research would include individuals experiencing fertility challenges or those interested in understanding genetic factors affecting reproduction.
✕Less likely to help
Patients who are not seeking to conceive or who do not have concerns related to fertility or genetic development may not benefit from this research.
What this research studies
This research investigates the differences in DNA methylation patterns between male and female reproductive cells, which are crucial for fertility and the development of offspring. It focuses on how these patterns are established and maintained, particularly looking at the role of specific enzymes and histone modifications. By studying primordial germ cells, the research aims to uncover the mechanisms that lead to these sex-specific differences in DNA methylation. This could provide insights into fertility issues and developmental problems linked to aberrant DNA methylation.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and potential treatments for fertility issues and developmental disorders related to DNA methylation.
How similar studies have gone: Other research has shown promising results in understanding DNA methylation and its implications for fertility, indicating that this area of study has potential for significant breakthroughs.
Where this research is happening
-
University of Pennsylvania
Philadelphia, United States Active
Researchers
- Principal investigator: Prasasya, Rexxi Diptya — University of Pennsylvania
- Study coordinator: Prasasya, Rexxi Diptya
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.