Understanding how DNA methylation affects the formation of heterochromatin
Role of DNA Methylation in Liquid-liquid Phase Separation-mediated Heterochromatin Formation
['FUNDING_OTHER'] · UPSTATE MEDICAL UNIVERSITY · NIH-10849867
This study is looking at how a process called DNA methylation helps shape the way our genes are packed and controlled, which could lead to better treatments for diseases like cancer.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UPSTATE MEDICAL UNIVERSITY (nih funded) |
| Locations | 1 site (SYRACUSE, UNITED STATES) |
| Trial ID | NIH-10849867 on ClinicalTrials.gov |
What this research studies
This research investigates the role of DNA methylation in the formation of heterochromatin, a tightly packed form of DNA that plays a crucial role in gene regulation. By examining how DNA methylation interacts with proteins involved in chromatin structure, the study aims to uncover the mechanisms that control gene expression and DNA repair processes. Patients may benefit from insights gained into how these processes can be manipulated to improve treatments for various diseases, including cancers. The research employs advanced techniques such as fluorescence microscopy to visualize these molecular interactions.
Who could benefit from this research
Good fit: Ideal candidates for this research include patients with cancers or genetic disorders related to chromatin dysfunction and DNA repair mechanisms.
Not a fit: Patients with conditions unrelated to chromatin structure or DNA methylation may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for treating cancers and other genetic disorders by targeting the mechanisms of gene regulation.
How similar studies have performed: While the specific approach of studying DNA methylation in relation to liquid-liquid phase separation is novel, similar research has shown promising results in understanding chromatin dynamics and gene regulation.
Where this research is happening
SYRACUSE, UNITED STATES
- UPSTATE MEDICAL UNIVERSITY — SYRACUSE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: BAH, ALAJI — UPSTATE MEDICAL UNIVERSITY
- Study coordinator: BAH, ALAJI
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Cancers, Disease, Disorder