Understanding how DNA loops are formed and organized in the genome
Cross-regulation between loop extrusion, chromatin fiber structure and chromatin-associated RNAs
This study is looking at how a special protein complex helps organize our DNA in a way that is important for our genes to work properly, which could help us understand and find new treatments for diseases like cancer and other developmental issues.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Rockefeller University NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10472889 on NIH RePORTER |
What this research studies
This research investigates the role of the cohesin complex in shaping the three-dimensional structure of the genome, which is crucial for proper gene expression. By examining how cohesin interacts with chromatin and DNA-binding proteins, the research aims to uncover the mechanisms that govern genome architecture. The approach involves advanced experimental techniques to analyze both small-scale and large-scale chromatin features, providing insights into how disruptions in these processes can lead to developmental diseases and cancers. Patients may benefit from a better understanding of these mechanisms, potentially leading to new therapeutic strategies.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research include individuals with genetic predispositions to cancers or developmental disorders linked to chromatin structure abnormalities.
Not a fit: Patients with conditions unrelated to chromatin structure or genome organization may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to novel treatments for cancers and developmental disorders by targeting the mechanisms of genome organization.
How similar studies have performed: Previous research has shown promising results in understanding genome organization, but this specific approach to studying cohesin's role is relatively novel.
Where this research is happening
New York, United States
- Rockefeller University — New York, United States (Active)
Researchers
- Principal investigator: Risca, Viviana I — Rockefeller University
- Study coordinator: Risca, Viviana I
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.