Understanding how DNA Ligase 1 affects Huntington's disease
Official title: Dissecting the role of DNA Ligase 1 in Huntington's disease
Funded at Massachusetts General Hospital · NIH-10892912 · Data updated 2026-11-12
This study is looking at how changes in a specific gene called DNA Ligase 1 might affect the progression of Huntington's disease, and it's using mice to help understand this better, with the hope of finding new ways to treat the condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Massachusetts General Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | July 25, 2023 |
| Project end | June 30, 2028 |
| Funding year | 2024 |
| Award (this year) | $640,064 |
| NIH project number | 5R01NS127866-02 |
| Project ID | NIH-10892912 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with Huntington's disease, particularly those with specific genetic markers related to DNA Ligase 1.
✕Less likely to help
Patients without a diagnosis of Huntington's disease or those who do not carry the relevant genetic markers may not benefit from this research.
What this research studies
This research investigates the role of DNA Ligase 1 in Huntington's disease, a severe neurodegenerative condition caused by genetic mutations. The study aims to explore how variations in the DNA Ligase 1 gene can influence the progression of the disease and its symptoms. By using a mouse model, researchers will examine the effects of specific genetic modifications on disease onset and cellular toxicity. This approach is grounded in human genetic data, aiming to uncover mechanisms that could lead to new treatment strategies.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic targets for delaying the onset or progression of Huntington's disease.
How similar studies have gone: Previous research has shown promising results in understanding genetic modifiers in neurodegenerative diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Massachusetts General Hospital
Boston, United States Active
Researchers
- Principal investigator: Wheeler, Vanessa C — Massachusetts General Hospital
- Study coordinator: Wheeler, Vanessa C
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.