Understanding how DNA is organized in the cell nucleus
Official title: Integrative models of nuclear DNA organization
Funded at University of Washington · NIH-10947527 · Data updated 2026-11-12
This study is looking at how the way DNA is arranged in our cells can affect how genes work, especially in cancer, and it aims to help us find better treatments for patients by understanding these important connections.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Washington NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project start | August 15, 2024 |
| Project end | July 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $131,338 |
| NIH project number | 1K99HG013663-01 |
| Project ID | NIH-10947527 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with genetic conditions or cancers that may be influenced by nuclear DNA organization.
✕Less likely to help
Patients with conditions unrelated to genetic regulation or nuclear architecture may not benefit from this research.
What this research studies
This research investigates how the organization of DNA within the cell nucleus affects gene regulation, particularly in the context of cancer. By utilizing advanced sequencing techniques like Hi-C and ATAC-seq, the study aims to uncover the sequence determinants that influence nuclear architecture and its implications for health and disease. The research employs deep learning models to analyze data from various human tissues and mammalian species, providing insights into the functional consequences of nuclear DNA organization. Patients may benefit from a better understanding of how these mechanisms contribute to diseases, potentially leading to improved treatments.
Why it matters
Potential benefit: If successful, this research could lead to new insights into gene regulation that may improve cancer treatment and other health conditions.
How similar studies have gone: Other research has shown promise in understanding DNA organization and its effects on gene regulation, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of Washington
Seattle, United States Active
Researchers
- Principal investigator: Jha, Anupama — University of Washington
- Study coordinator: Jha, Anupama
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.