Understanding how DNA is organized in 3D within cells
Genomes in 3D: from maps to mechanisms
This study is looking at how DNA is arranged inside cells and how that affects how genes work, which could help us understand genetic diseases better.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Southern California NIH-funded |
| Lab location | 1 site (Los Angeles, UNITED STATES) |
| Project ID | NIH-11127483 on NIH RePORTER |
What this research studies
This research investigates the three-dimensional organization of DNA within cells and how this structure influences genetic functions. By utilizing advanced techniques from biophysics, bioinformatics, and machine learning, the project aims to develop computational models that reveal the sequences and mechanisms behind genome folding. The researchers will explore how different cell types organize their genomes and how these arrangements affect gene regulation and expression. This work could lead to new insights into genetic diseases and cellular functions.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with genetic conditions or those interested in the genetic basis of diseases.
Not a fit: Patients without genetic disorders or those not interested in genetic research may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could enhance our understanding of genetic regulation and lead to improved treatments for genetic disorders.
How similar studies have performed: Other research has shown promising results in understanding genome organization, making this approach a continuation of successful methodologies.
Where this research is happening
Los Angeles, UNITED STATES
- University of Southern California — Los Angeles, United States (Active)
Researchers
- Principal investigator: Fudenberg, Geoffrey — University of Southern California
- Study coordinator: Fudenberg, Geoffrey
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.