Understanding how DNA is organized and accessed in crowded environments
Physical determinants of DNA recognition and genome organization in crowded environments
This study is looking at how DNA and the stuff around it work together in crowded cells, using cool lab tools to better understand how genes are controlled and how they can change, which could help us learn more about important biological processes.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Univ of Massachusetts Med Sch Worcester NIH-funded |
| Lab location | 1 site (Worcester, United States) |
| Project ID | NIH-10872200 on NIH RePORTER |
What this research studies
This research investigates the organization and accessibility of genomic information, focusing on how DNA and chromatin behave in crowded cellular environments. By utilizing advanced experimental techniques such as DNA and chromatin curtains, optical tweezers, and droplet experiments, the research aims to explore the physical properties of chromatin and its role in biological processes. The goal is to connect laboratory findings with real-life cellular behavior, enhancing our understanding of gene regulation and epigenetic mechanisms.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with conditions related to genomic instability or epigenetic disorders.
Not a fit: Patients with conditions unrelated to DNA organization or chromatin structure may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights into gene regulation and potential therapeutic strategies for diseases related to genomic instability.
How similar studies have performed: While the specific approaches used in this research are innovative, similar studies have shown promise in understanding chromatin behavior and its implications in biology.
Where this research is happening
Worcester, United States
- Univ of Massachusetts Med Sch Worcester — Worcester, United States (Active)
Researchers
- Principal investigator: Redding, Sy — Univ of Massachusetts Med Sch Worcester
- Study coordinator: Redding, Sy
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.