Understanding how DNA is copied in cells and its implications for diseases like cancer
Official title: Molecular mechanism of eukaryotic chromosome replication
Funded at Sloan-Kettering Inst Can Research · NIH-10765321 · Data updated 2026-11-12
This study is looking at how our cells copy their DNA and what happens when things go wrong, which can lead to problems like cancer, and it's for anyone interested in understanding how our bodies keep their genetic information safe and healthy.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Sloan-Kettering Inst Can Research NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | August 10, 2024 |
| Project end | July 31, 2029 |
| Funding year | 2024 |
| Award (this year) | $675,277 |
| NIH project number | 1R35GM152094-01 |
| Project ID | NIH-10765321 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with a history of cancer or genetic predispositions to genomic instability.
✕Less likely to help
Patients with conditions unrelated to DNA replication stress or those not at risk for genomic instability may not benefit from this research.
What this research studies
This research investigates the molecular mechanisms behind DNA replication in eukaryotic cells, particularly focusing on how replication stress can lead to genome instability, a key factor in diseases such as cancer. By using advanced techniques with purified proteins from budding yeast and humans, the researchers aim to understand how DNA replication is accurately and rapidly completed during normal cell growth. The study will explore how various physical obstacles on DNA can disrupt this process and how cells can overcome these challenges to maintain genomic stability.
Why it matters
Potential benefit: If successful, this research could lead to new insights into cancer prevention and treatment by enhancing our understanding of DNA replication and its associated stresses.
How similar studies have gone: Previous research has shown promising results in understanding DNA replication mechanisms, indicating that this approach could yield valuable insights.
Where this research is happening
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Sloan-Kettering Inst Can Research
New York, United States Active
Researchers
- Principal investigator: Remus, Dirk — Sloan-Kettering Inst Can Research
- Study coordinator: Remus, Dirk
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.