Understanding how DNA is copied and repaired in cells
Official title: Biochemistry of Eukaryotic Replication Fork and DNA Repair
Funded at Rockefeller University · NIH-11090507 · Data updated 2026-11-12
This study is looking at how our cells copy and fix their DNA, which is really important for keeping us healthy, and it's especially for anyone interested in understanding more about genetic disorders and cancers that can happen when these processes go wrong.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Rockefeller University NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | September 1, 2023 |
| Project end | May 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $423,750 |
| NIH project number | 5R35GM148159-03 |
| Project ID | NIH-11090507 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with genetic disorders related to DNA replication, such as ataxia telangiectasia.
✕Less likely to help
Patients with conditions unrelated to DNA replication or repair mechanisms may not benefit from this research.
What this research studies
This research investigates the complex machinery involved in DNA replication and repair, focusing on the eukaryotic replisome, which is essential for maintaining genetic integrity. By using biochemical techniques and single-molecule methods, the team aims to understand how specific proteins interact during DNA synthesis and repair processes. The study involves purifying proteins from yeast and analyzing their structures to gain insights into their functions. This knowledge could lead to advancements in understanding genetic disorders and cancers linked to DNA replication errors.
Why it matters
Potential benefit: If successful, this research could improve our understanding of genetic diseases and lead to new treatments for cancers associated with DNA replication errors.
How similar studies have gone: Previous research has shown promising results in understanding DNA replication mechanisms, indicating that this approach could yield valuable insights.
Where this research is happening
-
Rockefeller University
New York, United States Active
Researchers
- Principal investigator: O'donnell, Michael E — Rockefeller University
- Study coordinator: O'donnell, Michael E
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.