Understanding how DNA is copied and organized in cells
Mechanisms of DNA Replication, Chromosome Compaction, and Chromosome Unlinking
['FUNDING_OTHER'] · SLOAN-KETTERING INST CAN RESEARCH · NIH-11054672
This study looks at how our cells copy their DNA and organize their chromosomes when they divide, especially when things go wrong, which can lead to problems like cancer, and it aims to find out how cells fix these issues to keep our genes stable.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | SLOAN-KETTERING INST CAN RESEARCH (nih funded) |
| Locations | 1 site (NEW YORK, UNITED STATES) |
| Trial ID | NIH-11054672 on ClinicalTrials.gov |
What this research studies
This research investigates the mechanisms behind DNA replication and chromosome organization during cell division. It focuses on how replication forks can stall due to various cellular stresses and obstacles, which can lead to genomic instability and potentially cancer. By examining the interactions between replication machinery and other cellular components, the research aims to uncover how cells can repair stalled replication forks and maintain genetic stability. This work involves advanced techniques to analyze human proteins and their roles in these processes.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with conditions related to genomic instability, such as certain types of cancer.
Not a fit: Patients with stable genetic conditions that do not involve issues with DNA replication or chromosomal organization may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing genomic instability, which is a key factor in cancer development.
How similar studies have performed: Other research has shown success in understanding DNA replication mechanisms, but this specific focus on human proteins and their interactions is relatively novel.
Where this research is happening
NEW YORK, UNITED STATES
- SLOAN-KETTERING INST CAN RESEARCH — NEW YORK, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: MARIANS, KENNETH J — SLOAN-KETTERING INST CAN RESEARCH
- Study coordinator: MARIANS, KENNETH J
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Cancers