Understanding how DNA is accessed in cells
Chromatin modifications that enhance DNA accessibility
This project explores how our cells open up tightly packed DNA, which could help us understand and treat conditions like cancer and HIV.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Northeastern University NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-11136395 on NIH RePORTER |
What this research studies
Our DNA is usually tightly folded inside cells, but it needs to be accessible for important processes like making proteins. This project looks at special helper proteins, like FACT, LEDGF, and HDGF2, that assist in unwrapping DNA without using extra energy. Researchers want to understand exactly how these proteins work to make DNA available, especially focusing on how they interact with specific DNA modifications. This basic understanding is crucial because these processes are linked to how viruses like HIV integrate into our DNA and how cancer cells grow.
Who could benefit from this research
Good fit: This foundational research does not involve direct patient participation but could eventually benefit patients with cancer or HIV by informing future treatments.
Not a fit: Patients seeking immediate treatment options would not directly benefit from this basic science project, as it focuses on fundamental biological mechanisms.
Why it matters
Potential benefit: If successful, this work could lead to new ways to target diseases like cancer and HIV by controlling how DNA is accessed within cells.
How similar studies have performed: The role of FACT as a DNA helper protein is well-known, but the specific mechanisms for LEDGF and HDGF2 are still being uncovered, making this a novel area of focus.
Where this research is happening
Boston, United States
- Northeastern University — Boston, United States (Active)
Researchers
- Principal investigator: Williams, Mark C — Northeastern University
- Study coordinator: Williams, Mark C
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.