Understanding how DNA influences the shape of organs
Physics of Living Matter: From Molecule to Embryo
['FUNDING_OTHER'] · UNIVERSITY OF CALIFORNIA SANTA BARBARA · NIH-10876982
This study is looking at how our genes affect the way heart cells work together to form a healthy heart, which could help us understand why some people are born with heart problems.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CALIFORNIA SANTA BARBARA (nih funded) |
| Locations | 1 site (SANTA BARBARA, UNITED STATES) |
| Trial ID | NIH-10876982 on ClinicalTrials.gov |
What this research studies
This research investigates the relationship between genetic information and the mechanical activities of cells that shape organs, particularly focusing on congenital heart disease. By combining principles from developmental biology and physics, the study aims to quantitatively analyze how cells interact and organize to form complex structures. The approach involves examining tissue dynamics at the organ scale to uncover new mechanisms of morphogenesis. This could lead to a better understanding of how defects in organ shape arise during development.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with congenital heart defects or those at risk of developing such conditions due to genetic factors.
Not a fit: Patients with acquired heart conditions unrelated to congenital defects may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could provide insights that lead to improved prevention and treatment strategies for congenital heart defects and other birth anomalies.
How similar studies have performed: While the integration of physics and developmental biology is a novel approach, similar studies have shown promise in understanding cellular interactions and organ formation.
Where this research is happening
SANTA BARBARA, UNITED STATES
- UNIVERSITY OF CALIFORNIA SANTA BARBARA — SANTA BARBARA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: STREICHAN, SEBASTIAN J — UNIVERSITY OF CALIFORNIA SANTA BARBARA
- Study coordinator: STREICHAN, SEBASTIAN J
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.