Understanding how DNA helicases work and are controlled
Mechanisms of DNA helicases and their regulation
['FUNDING_OTHER'] · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · NIH-11030751
This study is looking at how certain proteins that help fix DNA damage work and are controlled in our cells, which could help us understand their role in diseases like cancer.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN (nih funded) |
| Locations | 1 site (CHAMPAIGN, UNITED STATES) |
| Trial ID | NIH-11030751 on ClinicalTrials.gov |
What this research studies
This research investigates the mechanisms by which DNA helicases, essential proteins that separate DNA strands, are regulated within cells. By focusing on specific helicases that play critical roles in responding to DNA damage, the study aims to uncover how these proteins function and are activated in different cellular contexts. The research employs biophysical methods to analyze the interactions and regulatory mechanisms of these helicases, which are important for maintaining genomic integrity. Insights from this work could lead to a better understanding of their roles in various diseases, including cancer.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with genetic predispositions to diseases related to DNA repair mechanisms or those diagnosed with certain types of cancer.
Not a fit: Patients with conditions unrelated to DNA damage or repair mechanisms may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for treating diseases associated with DNA damage, including various cancers.
How similar studies have performed: Previous research has shown success in understanding the roles of helicases in DNA repair, indicating that this approach has a foundation in established scientific knowledge.
Where this research is happening
CHAMPAIGN, UNITED STATES
- UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN — CHAMPAIGN, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: CHEMLA, YANN R. — UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN
- Study coordinator: CHEMLA, YANN R.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Cancers