Understanding how DNA helicases maintain genome stability and prevent diseases.
DNA helicases and associated factors in genome stability
This study is looking at how certain proteins called DNA helicases work and how changes in their genes might cause diseases like cancer and Fanconi anemia, with the hope that understanding this could help develop better treatments for people at risk for these conditions.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Trustees of Indiana University NIH-funded |
| Lab location | 1 site (Bloomington, United States) |
| Project ID | NIH-10683104 on NIH RePORTER |
What this research studies
This research investigates the role of DNA helicases, which are essential enzymes involved in DNA replication, repair, and maintenance. By studying specific helicases like PIF1 and RecQ, the project aims to uncover how mutations in these genes can lead to diseases, including various cancers and conditions like Fanconi anemia. The research employs both in vivo and in vitro methods to explore the mechanisms of helicase function and their impact on genome integrity. This knowledge could bridge the gap between basic science and clinical applications, potentially leading to improved treatments for patients with genetic predispositions to these diseases.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with a family history of cancers or genetic disorders related to DNA repair, such as Fanconi anemia.
Not a fit: Patients with conditions unrelated to DNA repair mechanisms or those without genetic predispositions to related diseases may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating cancers and genetic disorders linked to DNA repair deficiencies.
How similar studies have performed: Previous research has shown promising results in understanding DNA repair mechanisms, indicating that this approach has the potential for significant breakthroughs.
Where this research is happening
Bloomington, United States
- Trustees of Indiana University — Bloomington, United States (Active)
Researchers
- Principal investigator: Bochman, Matthew Linne — Trustees of Indiana University
- Study coordinator: Bochman, Matthew Linne
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.