Understanding how DNA helicases maintain genome stability
DNA helicases and associated factors in genome stability
This study is looking at how certain proteins help keep our DNA healthy and how changes in these proteins can lead to diseases, with the goal of finding better treatments for people who have these genetic issues.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Trustees of Indiana University NIH-funded |
| Lab location | 1 site (Bloomington, United States) |
| Project ID | NIH-10788644 on NIH RePORTER |
What this research studies
This research investigates the role of DNA helicases in maintaining the integrity of our genetic material. By studying specific helicases, such as PIF1 and RecQ, the research aims to uncover how mutations in these genes can lead to various diseases. The approach combines traditional laboratory techniques with advanced methods like next-generation sequencing and mass spectrometry to gain insights into DNA repair processes. This work is crucial for linking genetic mutations to potential treatments for patients affected by helicase-related disorders.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with genetic mutations affecting DNA helicases or related disorders.
Not a fit: Patients without mutations in helicase genes or those not affected by DNA repair disorders may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic targets and treatments for diseases linked to DNA helicase mutations.
How similar studies have performed: Previous research has shown promising results in understanding DNA repair mechanisms, suggesting that this approach could yield significant insights.
Where this research is happening
Bloomington, United States
- Trustees of Indiana University — Bloomington, United States (Active)
Researchers
- Principal investigator: Bochman, Matthew Linne — Trustees of Indiana University
- Study coordinator: Bochman, Matthew Linne
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.