Understanding how DNA helicases help maintain genome stability
DNA helicases and associated factors in genome stability
This study is looking at how certain proteins called DNA helicases help fix our DNA and what happens when they don't work right, which could lead to diseases like cancer, so we can find better treatments for people affected by these issues.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Trustees of Indiana University NIH-funded |
| Lab location | 1 site (Bloomington, United States) |
| Project ID | NIH-10726902 on NIH RePORTER |
What this research studies
This research investigates the role of DNA helicases, which are essential enzymes involved in DNA replication, repair, and maintenance. By studying specific helicases like PIF1 and RecQ, the research aims to uncover how mutations in these genes can lead to diseases, including various cancers. The approach includes both laboratory experiments and analysis of genetic factors to understand the mechanisms behind DNA damage repair and genome integrity. Patients may benefit from insights that could lead to improved treatments for conditions linked to helicase dysfunction.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with genetic mutations associated with Fanconi anemia or other conditions linked to DNA repair deficiencies.
Not a fit: Patients without genetic mutations affecting DNA repair mechanisms may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and treatment options for patients with genetic predispositions to cancers and other diseases related to DNA repair.
How similar studies have performed: Previous research has shown promising results in understanding the role of helicases in genome stability, indicating that this area of study has potential for significant advancements.
Where this research is happening
Bloomington, United States
- Trustees of Indiana University — Bloomington, United States (Active)
Researchers
- Principal investigator: Bochman, Matthew Linne — Trustees of Indiana University
- Study coordinator: Bochman, Matthew Linne
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.