Understanding How DNA Handles Stress
Analysis of the Replication Stress Response
This project aims to understand how our DNA repairs itself when it faces challenges, which is important for developing new cancer treatments.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Vanderbilt University NIH-funded |
| Lab location | 1 site (Nashville, UNITED STATES) |
| Project ID | NIH-11139547 on NIH RePORTER |
What this research studies
Our bodies constantly replicate billions of DNA building blocks, but this process can be interrupted by damage or difficult sequences. This research explores the natural ways our cells cope with these 'replication stresses' to complete DNA copying and prevent errors. We are particularly interested in how DNA forks, the structures where DNA is actively being copied, can reverse to fix problems. By using advanced lab techniques, we hope to uncover the precise steps involved in these repair mechanisms.
Who could benefit from this research
Good fit: This foundational research does not directly involve patient participation, but its findings are relevant to patients with various types of cancer.
Not a fit: Patients seeking immediate treatment options would not directly benefit from this basic science project.
Why it matters
Potential benefit: If successful, this work could lead to a deeper understanding of cancer development and resistance to therapy, potentially guiding the creation of more effective cancer treatments.
How similar studies have performed: This project builds upon many years of accumulated knowledge in DNA replication and repair, incorporating recent discoveries to explore new conceptual models.
Where this research is happening
Nashville, UNITED STATES
- Vanderbilt University — Nashville, United States (Active)
Researchers
- Principal investigator: Cortez, David K — Vanderbilt University
- Study coordinator: Cortez, David K
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.