Understanding how DNA gaps form and are repaired
Creation and Repair of Postreplicative DNA Gaps
This study is looking at how our DNA can get damaged and create gaps, which might lead to problems like cancer and antibiotic resistance, and the researchers hope to find better ways to fix these gaps to improve treatments for these issues.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Wisconsin-Madison NIH-funded |
| Lab location | 1 site (Madison, United States) |
| Project ID | NIH-10847073 on NIH RePORTER |
What this research studies
This research investigates the processes involved when DNA replication encounters damage, leading to gaps in the DNA strand. It focuses on understanding how these gaps can contribute to genome instability, which is linked to cancer evolution and antibiotic resistance in bacteria. The researchers are developing new methods to explore the significance of these gaps and how they are repaired, which could lead to breakthroughs in treating related conditions. By studying these mechanisms, the research aims to provide insights into improving DNA repair processes.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with conditions related to DNA repair deficiencies, such as certain cancers or those affected by antibiotic-resistant infections.
Not a fit: Patients with no known issues related to DNA repair or antibiotic resistance may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing cancer and combating antibiotic resistance.
How similar studies have performed: Other research has shown success in understanding DNA repair mechanisms, making this approach promising but still exploring novel aspects.
Where this research is happening
Madison, United States
- University of Wisconsin-Madison — Madison, United States (Active)
Researchers
- Principal investigator: Cox, Michael M. — University of Wisconsin-Madison
- Study coordinator: Cox, Michael M.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.