Understanding how DNA damage repair issues affect prostate cancer
The Impact of DNA Damage Repair Abnormalities in Prostate Cancer
['FUNDING_P01'] · SLOAN-KETTERING INST CAN RESEARCH · NIH-10922756
This study is looking at how problems with DNA repair might affect prostate cancer in men, especially those with more serious forms of the disease, to help find better ways to catch and treat it early.
Quick facts
| Phase | ['FUNDING_P01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | SLOAN-KETTERING INST CAN RESEARCH (nih funded) |
| Locations | 1 site (NEW YORK, UNITED STATES) |
| Trial ID | NIH-10922756 on ClinicalTrials.gov |
What this research studies
This research investigates the role of DNA damage repair (DDR) abnormalities in prostate cancer, particularly focusing on men diagnosed with localized and aggressive forms of the disease. By analyzing genetic variations in DDR pathway genes, the study aims to identify how these abnormalities contribute to the progression of prostate cancer, especially in cases that may lead to metastatic castration-resistant prostate cancer (mCRPC). The research employs a combination of genetic analysis and clinical data to characterize the impact of these genetic factors on patient outcomes, with the goal of improving early intervention strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research include men diagnosed with localized prostate cancer, particularly those at high risk for aggressive disease.
Not a fit: Patients with advanced metastatic prostate cancer who are not in the localized stage may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better-targeted therapies and personalized treatment plans for men with prostate cancer.
How similar studies have performed: Previous research has shown promising results in understanding the role of DNA repair mechanisms in cancer, indicating that this approach has potential for significant advancements in treatment.
Where this research is happening
NEW YORK, UNITED STATES
- SLOAN-KETTERING INST CAN RESEARCH — NEW YORK, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: OFFIT, KENNETH — SLOAN-KETTERING INST CAN RESEARCH
- Study coordinator: OFFIT, KENNETH
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Cancer Cause, Cancer Etiology, Cancers