Understanding how DNA damage leads to mutations in human tissues
Official title: Davoli/Mita Diversity Supplement
Funded at New York University School of Medicine · NIH-11090156 · Data updated 2026-11-12
This study is looking at how our genes can change and cause problems in our cells, especially in cancer cells, and it's testing a new tool to see how often these changes happen, which could help us understand more about diseases like cancer.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | New York University School of Medicine NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | September 15, 2023 |
| Project end | June 30, 2027 |
| Funding year | 2024 |
| Award (this year) | $124,979 |
| NIH project number | 3R01HG012590-02S1 |
| Project ID | NIH-11090156 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with a history of cancer or those at high risk for developing cancer due to genetic or environmental factors.
✕Less likely to help
Patients with conditions unrelated to DNA damage or mutation processes may not benefit from this research.
What this research studies
This research investigates the genetic causes of mutations in human tissues and how different cell types manage DNA damage and repair. By developing a novel tool called MutSensor, the researchers aim to measure DNA mutation frequency in mammalian cells with unprecedented sensitivity. The study will utilize advanced genetic techniques to identify genes that influence mutation rates in various human cell types, including cancer cells. This comprehensive approach seeks to deepen our understanding of how mutations contribute to diseases like cancer.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for preventing and treating cancer by targeting the mechanisms of DNA damage and repair.
How similar studies have gone: Other research has shown success in understanding DNA damage and repair mechanisms, but this approach using MutSensor is innovative and aims to provide new insights.
Where this research is happening
-
New York University School of Medicine
New York, United States Active
Researchers
- Principal investigator: Davoli, Teresa — New York University School of Medicine
- Study coordinator: Davoli, Teresa
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.