Understanding how DNA damage contributes to Alzheimer's disease and cancer
Mechanisms of Endogenous DNA Damage Promotion
This study is looking at how certain proteins can harm DNA and may be connected to Alzheimer's disease and cancer, with the hope of finding new ways to diagnose and treat these conditions for patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Baylor College of Medicine NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project ID | NIH-10861835 on NIH RePORTER |
What this research studies
This research investigates the mechanisms by which certain proteins can cause DNA damage, which is linked to both Alzheimer's disease and cancer. By studying these proteins in bacteria and their human counterparts, the team aims to identify new biomarkers and potential treatments for Alzheimer's disease. The project focuses on understanding how the overproduction of specific proteins leads to genome instability, which may contribute to the development of these diseases. Patients may benefit from new diagnostic and therapeutic strategies that arise from this research.
Who could benefit from this research
Good fit: Ideal candidates include individuals at risk for Alzheimer's disease or those with early symptoms of cognitive decline.
Not a fit: Patients with advanced Alzheimer's disease or those not at risk for the condition may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new ways to diagnose and treat Alzheimer's disease and potentially improve patient outcomes.
How similar studies have performed: Previous research has shown promising results in understanding the links between DNA damage and cancer, suggesting that this approach may yield valuable insights for Alzheimer's disease as well.
Where this research is happening
Houston, United States
- Baylor College of Medicine — Houston, United States (Active)
Researchers
- Principal investigator: Rosenberg, Susan M — Baylor College of Medicine
- Study coordinator: Rosenberg, Susan M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.