Understanding how DNA damage and replication are connected
DNA Damage & DNA Replication: a Complex Relationship
This study looks at how a special protein complex helps another important protein respond to DNA damage, which is key for keeping our cells healthy, and it could help us understand more about certain cancers and genetic disorders that happen when DNA doesn't work right.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Sloan-Kettering Inst Can Research NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10915629 on NIH RePORTER |
What this research studies
This research investigates the mechanisms by which the Mre11 complex activates the ATM protein, which is crucial for responding to DNA damage. It explores how this complex influences DNA replication and how it helps cells cope with replication stress, particularly at the telomeres. Using a combination of genetic studies in yeast and mouse models, as well as biochemical techniques, the research aims to uncover the roles of specific proteins in maintaining genomic stability. Patients may benefit from insights gained into the underlying causes of certain cancers and genetic disorders related to DNA damage.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research include individuals with genetic predispositions to cancers or conditions related to DNA repair deficiencies.
Not a fit: Patients with conditions unrelated to DNA damage or replication stress may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for cancers and genetic disorders associated with DNA damage.
How similar studies have performed: Previous research has shown promising results in understanding DNA damage responses, indicating that this approach has potential for significant findings.
Where this research is happening
New York, United States
- Sloan-Kettering Inst Can Research — New York, United States (Active)
Researchers
- Principal investigator: Petrini, John Hj — Sloan-Kettering Inst Can Research
- Study coordinator: Petrini, John Hj
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.