Understanding how DNA damage and repair affects cancer treatment and prevention
DNA Adduct Detection and Repair in Mammalian Cells
['FUNDING_R01'] · UNIV OF NORTH CAROLINA CHAPEL HILL · NIH-10873175
This study looks at how different things in our environment can harm our DNA and how our bodies fix that damage, with the goal of finding better ways to prevent cancer and create treatments that work well with fewer side effects for patients.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIV OF NORTH CAROLINA CHAPEL HILL (nih funded) |
| Locations | 1 site (CHAPEL HILL, UNITED STATES) |
| Trial ID | NIH-10873175 on ClinicalTrials.gov |
What this research studies
This research investigates how various environmental and chemical agents cause DNA damage in mammalian cells and how the body repairs this damage. By using advanced techniques to map the locations of DNA lesions and the repair processes, the study aims to uncover the relationship between DNA damage, cancer development, and the effectiveness of anti-cancer drugs. Patients may benefit from insights that could lead to improved cancer prevention strategies and more effective treatments with fewer side effects.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals exposed to environmental carcinogens or those undergoing cancer treatment.
Not a fit: Patients with no history of cancer or exposure to known carcinogens may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to better strategies for preventing cancer and designing more effective cancer treatments.
How similar studies have performed: Previous research has shown promising results in understanding DNA damage and repair mechanisms, indicating that this approach could yield valuable insights.
Where this research is happening
CHAPEL HILL, UNITED STATES
- UNIV OF NORTH CAROLINA CHAPEL HILL — CHAPEL HILL, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SANCAR, AZIZ — UNIV OF NORTH CAROLINA CHAPEL HILL
- Study coordinator: SANCAR, AZIZ
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Anti-Cancer Agents