Understanding how DNA damage affects inflammation regulation
Cooption of the DNA Damage Response For Epigenetic Regulation of Inflammation
This study is looking at how a special part of our cells' DNA repair system can affect inflammation, especially in immune cells called macrophages, to help us understand how our bodies respond to different signals from the environment.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Weill Medical Coll of Cornell Univ NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10738261 on NIH RePORTER |
What this research studies
This research investigates how the DNA damage response (DDR) can influence the regulation of inflammation at the genetic level. By focusing on a specific histone protein variant, H3.3, the study aims to uncover the mechanisms that allow cells, particularly macrophages, to rapidly activate inflammatory genes in response to environmental signals. The researchers will use advanced mouse models to explore the interactions between DDR factors and histone modifications, which could reveal new insights into the regulation of inflammation and immune responses.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with autoimmune diseases or conditions characterized by chronic inflammation.
Not a fit: Patients with non-inflammatory conditions or those not affected by autoimmune diseases may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for managing inflammatory diseases and autoimmune conditions.
How similar studies have performed: Previous research has shown promising results in understanding the role of histone modifications in gene regulation, suggesting that this approach could yield valuable insights.
Where this research is happening
New York, United States
- Weill Medical Coll of Cornell Univ — New York, United States (Active)
Researchers
- Principal investigator: Josefowicz, Steven Zvi — Weill Medical Coll of Cornell Univ
- Study coordinator: Josefowicz, Steven Zvi
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.