Understanding how DNA damage affects inflammation in cells
Official title: NF-KB regulation by the DNA damage response
Funded at University of California-Irvine · NIH-11056607 · Data updated 2026-11-12
This study is looking at how a protein called NF-κB, which helps control inflammation, reacts when our DNA gets damaged by things in our environment, and it’s for anyone interested in understanding how our body's immune system responds to such damage.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California-Irvine NIH-funded |
| Lab location | 1 site (Irvine, United States) |
| Project start | January 9, 2025 |
| Project end | January 8, 2027 |
| Funding year | 2025 |
| Award (this year) | $431,750 |
| NIH project number | 1R21ES036190-01A1 |
| Project ID | NIH-11056607 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals experiencing age-related diseases or conditions associated with DNA damage.
✕Less likely to help
Patients with conditions unrelated to DNA damage or inflammation may not benefit from this research.
What this research studies
This research investigates the role of NF-κB, a key protein involved in inflammation, in response to DNA damage caused by environmental stress. It focuses on how DNA damage in the nucleus triggers NF-κB activation in the cytoplasm through a signaling pathway regulated by the ATM kinase. The study aims to uncover additional pathways that may activate NF-κB when DNA damage occurs, especially when traditional gene expression processes are blocked. By exploring these mechanisms, the research seeks to enhance our understanding of the innate immune response in the context of DNA damage.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for enhancing the immune response in patients with age-related diseases linked to DNA damage.
How similar studies have gone: Previous research has shown promising results in understanding NF-κB activation pathways, but this specific approach is novel and aims to fill existing knowledge gaps.
Where this research is happening
-
University of California-Irvine
Irvine, United States Active
Researchers
- Principal investigator: Buisson, Remi — University of California-Irvine
- Study coordinator: Buisson, Remi
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.