Understanding how DNA damage affects inflammation in cells
NF-KB regulation by the DNA damage response
['FUNDING_R21'] · UNIVERSITY OF CALIFORNIA-IRVINE · NIH-11056607
This study is looking at how a protein called NF-κB, which helps control inflammation, reacts when our DNA gets damaged by things in our environment, and it’s for anyone interested in understanding how our body's immune system responds to such damage.
Quick facts
| Phase | ['FUNDING_R21'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CALIFORNIA-IRVINE (nih funded) |
| Locations | 1 site (IRVINE, UNITED STATES) |
| Trial ID | NIH-11056607 on ClinicalTrials.gov |
What this research studies
This research investigates the role of NF-κB, a key protein involved in inflammation, in response to DNA damage caused by environmental stress. It focuses on how DNA damage in the nucleus triggers NF-κB activation in the cytoplasm through a signaling pathway regulated by the ATM kinase. The study aims to uncover additional pathways that may activate NF-κB when DNA damage occurs, especially when traditional gene expression processes are blocked. By exploring these mechanisms, the research seeks to enhance our understanding of the innate immune response in the context of DNA damage.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals experiencing age-related diseases or conditions associated with DNA damage.
Not a fit: Patients with conditions unrelated to DNA damage or inflammation may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for enhancing the immune response in patients with age-related diseases linked to DNA damage.
How similar studies have performed: Previous research has shown promising results in understanding NF-κB activation pathways, but this specific approach is novel and aims to fill existing knowledge gaps.
Where this research is happening
IRVINE, UNITED STATES
- UNIVERSITY OF CALIFORNIA-IRVINE — IRVINE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: BUISSON, REMI — UNIVERSITY OF CALIFORNIA-IRVINE
- Study coordinator: BUISSON, REMI
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: age associated disease, age associated disorder, age dependent disease, age dependent disorder, age related human disease