Understanding how DNA damage affects immune cell development
RAG-mediated DNA Damage Responses in Immune Development and Function
['FUNDING_R01'] · WASHINGTON UNIVERSITY · NIH-10894197
This study looks at how damage to DNA affects the growth and function of immune cells called B cells, with the goal of finding ways to prevent problems like leukemia, which could help patients manage or treat conditions like acute B-lymphocytic leukemia.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | WASHINGTON UNIVERSITY (nih funded) |
| Locations | 1 site (SAINT LOUIS, UNITED STATES) |
| Trial ID | NIH-10894197 on ClinicalTrials.gov |
What this research studies
This research investigates the role of DNA damage in the development and function of immune cells, particularly B cells. It focuses on how specific DNA breaks, caused by the RAG endonuclease, influence the growth and maturation of these cells. By examining the signals that regulate these processes, the research aims to uncover mechanisms that prevent abnormal cell growth, which can lead to leukemia. Patients may benefit from insights into how to better manage or treat conditions like acute B-lymphocytic leukemia.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with acute B-lymphocytic leukemia or those at risk for developing this condition.
Not a fit: Patients with other types of leukemia or unrelated blood disorders may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for patients with acute B-lymphocytic leukemia by enhancing our understanding of immune cell development.
How similar studies have performed: Other research has shown promising results in understanding DNA damage responses in immune cells, indicating that this approach has potential for significant advancements.
Where this research is happening
SAINT LOUIS, UNITED STATES
- WASHINGTON UNIVERSITY — SAINT LOUIS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: BEDNARSKI, JEFFREY J — WASHINGTON UNIVERSITY
- Study coordinator: BEDNARSKI, JEFFREY J
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.