Understanding how DNA damage affects cancer development
ATM activation by DNA single-strand breaks
This study is looking at how damage to DNA from things like pollution and cancer treatments triggers a special protein that helps fix the DNA, and by understanding this process better, we hope to find new ways to help people with cancer and brain diseases.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of North Carolina Charlotte NIH-funded |
| Lab location | 1 site (Charlotte, United States) |
| Project ID | NIH-10489679 on NIH RePORTER |
What this research studies
This research investigates how single-strand breaks in DNA, which can be caused by environmental toxins and chemotherapy, activate a protein called ATM that is crucial for DNA repair. By studying these processes in a controlled laboratory setting, the researchers aim to uncover the mechanisms behind ATM activation and its role in maintaining genome stability. The findings could lead to better understanding of cancer and neurodegenerative disorders, potentially informing new treatment strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with a history of cancer or those exposed to environmental toxins that may cause DNA damage.
Not a fit: Patients with conditions unrelated to DNA damage or those who do not have a history of cancer may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved therapies for cancer and other diseases related to DNA damage.
How similar studies have performed: Other research has shown success in understanding DNA repair mechanisms, making this approach promising but still exploring new aspects of ATM activation.
Where this research is happening
Charlotte, United States
- University of North Carolina Charlotte — Charlotte, United States (Active)
Researchers
- Principal investigator: Yan, Shan — University of North Carolina Charlotte
- Study coordinator: Yan, Shan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.