Understanding how DNA copies itself to prevent cancer
Mechanisms of replication origin licensing studied by real-time single-molecule fluorescence
This project aims to understand the basic steps of how our cells copy their DNA, which is crucial for preventing diseases like cancer.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Massachusetts Institute of Technology NIH-funded |
| Lab location | 1 site (Cambridge, United States) |
| Project ID | NIH-11124109 on NIH RePORTER |
What this research studies
Our bodies constantly make new cells, and each time, the DNA inside these cells must be perfectly copied. This copying process starts with special proteins that prepare the DNA for replication. When these proteins don't work correctly, it can lead to errors that contribute to serious conditions, including cancer. This project uses a very precise method called single-molecule fluorescence to watch these DNA copying steps in real-time. By seeing exactly how these proteins interact with DNA, we hope to uncover new ways to keep our cells healthy and prevent disease.
Who could benefit from this research
Good fit: Patients with cancers or developmental abnormalities linked to DNA replication errors might eventually benefit from future treatments stemming from this fundamental research.
Not a fit: Patients whose conditions are not related to DNA replication mechanisms would likely not receive direct benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could reveal new targets for developing treatments that correct DNA copying errors, potentially leading to new therapies for cancer and other related conditions.
How similar studies have performed: Previous biochemical methods have helped understand DNA replication, but this project uses a novel, real-time single-molecule approach to overcome limitations and provide more detailed insights.
Where this research is happening
Cambridge, United States
- Massachusetts Institute of Technology — Cambridge, United States (Active)
Researchers
- Principal investigator: Bell, Stephen P. — Massachusetts Institute of Technology
- Study coordinator: Bell, Stephen P.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.