Understanding how DNA changes lead to cancer
Mechanism of transcription-associated genome instability
This work explores how changes in our genetic material, called the genome, happen more often in certain areas and contribute to diseases like cancer.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas at Austin NIH-funded |
| Lab location | 1 site (Austin, United States) |
| Project ID | NIH-11132725 on NIH RePORTER |
What this research studies
Our bodies' genetic material, DNA, is constantly active, with many proteins moving along it, unwinding it, and sometimes causing distortions. This project looks at how these busy processes, especially when DNA is being copied or used to make proteins, can lead to mistakes or damage in the DNA. We are particularly interested in why these changes, which can cause diseases like cancer, tend to occur in specific 'hotspots' within the genome. By understanding these fundamental mechanisms, we hope to uncover new ways that DNA instability contributes to serious health conditions.
Who could benefit from this research
Good fit: This basic science work is not recruiting patients directly but is highly relevant to anyone affected by or at risk for cancer.
Not a fit: Patients seeking immediate treatment options would not directly benefit from this foundational laboratory research.
Why it matters
Potential benefit: If successful, this foundational work could lead to a deeper understanding of how cancer develops, potentially opening doors for new ways to prevent or treat the disease.
How similar studies have performed: The principal investigator's previous work has already shown that certain types of DNA errors are elevated during active gene processes, leading to new models of genome instability.
Where this research is happening
Austin, United States
- University of Texas at Austin — Austin, United States (Active)
Researchers
- Principal investigator: Kim, Nayun — University of Texas at Austin
- Study coordinator: Kim, Nayun
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.