Understanding how DNA changes in older adults affect their health
Official title: Gene regulatory network modeling of disease-associated DNA methylation perturbations
Funded at Cincinnati Childrens Hosp Med Ctr · NIH-11089406 · Data updated 2026-11-12
This study is looking at how certain gene changes related to DNA can affect the health of older adults, especially those over 65, to better understand age-related diseases and improve future treatments.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cincinnati Childrens Hosp Med Ctr NIH-funded |
| Lab location | 1 site (Cincinnati, United States) |
| Project start | June 1, 2023 |
| Project end | May 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $762,041 |
| NIH project number | 5R01AI173314-03 |
| Project ID | NIH-11089406 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults aged 65 and older who may have mutations in the DNMT3A or TET2 genes.
✕Less likely to help
Patients under the age of 65 or those without the specific genetic mutations being studied may not benefit from this research.
What this research studies
This research investigates how specific mutations in genes related to DNA methylation impact the health of older adults, particularly those over 65. By using advanced human stem cell models, the study aims to understand how these mutations can lead to various age-related diseases and increased mortality. The researchers will employ computational modeling to connect changes in DNA methylation to immune system responses, potentially revealing new insights into disease mechanisms. This approach may help identify at-risk individuals and inform future treatments.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and management of age-related diseases, improving health outcomes for older adults.
How similar studies have gone: Previous research has shown that understanding genetic mutations and their effects on health can lead to significant advancements in treatment and prevention strategies, suggesting this approach has potential for success.
Where this research is happening
-
Cincinnati Childrens Hosp Med Ctr
Cincinnati, United States Active
Researchers
- Principal investigator: Miraldi, Emily — Cincinnati Childrens Hosp Med Ctr
- Study coordinator: Miraldi, Emily
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.