Understanding how DNA changes happen in our bodies
Mechanisms and consequences of sequence context-dependency of human mutation rate
This research helps us understand why changes in our DNA happen in certain places more than others, which is important for understanding diseases like cancer.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pennsylvania NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-11143008 on NIH RePORTER |
What this research studies
This project aims to uncover the hidden rules behind how our DNA changes, or mutates, which is the root of many diseases, including cancer. We know that mutations don't happen randomly; some parts of our DNA are more prone to change than others, especially in specific sequences. By using powerful computer methods and existing genetic data, scientists hope to figure out the exact molecular reasons for these differences. This deeper understanding could help us better identify genes that cause disease and improve how we interpret genetic information.
Who could benefit from this research
Good fit: This foundational research does not directly involve patient participation but aims to benefit anyone affected by genetic diseases or cancer by improving our understanding of their origins.
Not a fit: Patients seeking immediate new treatments or direct clinical intervention would not find direct benefit from this basic science project.
Why it matters
Potential benefit: A better understanding of DNA mutation patterns could lead to improved ways to identify disease-causing genes and potentially develop more targeted treatments for conditions like cancer.
How similar studies have performed: While the concept of mutation rate variation is known, this project aims to develop novel computational methods to mechanistically understand these variations, building on existing genomic data.
Where this research is happening
Philadelphia, United States
- University of Pennsylvania — Philadelphia, United States (Active)
Researchers
- Principal investigator: Gao, Ziyue — University of Pennsylvania
- Study coordinator: Gao, Ziyue
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.