Understanding how DNA changes during mammal development
Official title: DNA Methylation Dynamics of Mammalian Development
Funded at Oregon Health & Science University · NIH-10853569 · Data updated 2026-11-12
This study is looking at how changes in DNA can affect the growth and development of mice, which might help us understand more about certain health issues and conditions that can arise during development.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Oregon Health & Science University NIH-funded |
| Lab location | 1 site (Portland, United States) |
| Project start | August 5, 2024 |
| Project end | July 31, 2029 |
| Funding year | 2024 |
| Award (this year) | $654,352 |
| NIH project number | 1R01HD114591-01 |
| Project ID | NIH-10853569 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with developmental disorders or those interested in the genetic and epigenetic factors influencing embryonic development.
✕Less likely to help
Patients who do not have developmental disorders or are not affected by epigenetic changes may not benefit from this research.
What this research studies
This research investigates the role of DNA methylation in the development of mammals, focusing on how this epigenetic modification influences cell lineage and gene expression. By utilizing advanced single-cell genomics techniques, the study aims to create a detailed atlas of DNA methylation changes during key stages of embryonic development in mice. This approach will allow researchers to explore the dynamics of DNA methylation at a resolution that has not been possible before, potentially uncovering links to developmental disorders and diseases.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and treatment of developmental disorders linked to abnormal DNA methylation.
How similar studies have gone: Other research has shown promising results in understanding epigenetic changes, but this specific approach using single-cell DNA methylation analysis is relatively novel.
Where this research is happening
-
Oregon Health & Science University
Portland, United States Active
Researchers
- Principal investigator: Adey, Andrew — Oregon Health & Science University
- Study coordinator: Adey, Andrew
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.