Understanding how DNA changes contribute to colon cancer
Mechanisms of DNA methylation signaling and dysregulation in colon cancer
This study is looking at how changes in DNA can affect the development of colon cancer, with the goal of finding new ways to treat patients by understanding what goes wrong in their cells.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Van Andel Research Institute NIH-funded |
| Lab location | 1 site (Grand Rapids, United States) |
| Project ID | NIH-10979595 on NIH RePORTER |
What this research studies
This research investigates the role of DNA methylation, a process that can silence tumor suppressor genes, in the development of colon cancer. It aims to uncover the mechanisms behind abnormal DNA methylation patterns and how they lead to cancer progression. The study will explore the involvement of protein modifications in regulating DNA methylation and assess potential therapeutic targets to correct these abnormalities. By understanding these processes, the research hopes to provide insights into new treatment strategies for colon cancer patients.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with colon cancer or those at high risk for developing the disease due to genetic factors.
Not a fit: Patients with non-colon cancers or those without any genetic predisposition to colon cancer may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that target the underlying mechanisms of colon cancer, potentially improving patient outcomes.
How similar studies have performed: Previous research has shown promising results in targeting DNA methylation and related pathways in cancer treatment, indicating that this approach has potential for success.
Where this research is happening
Grand Rapids, United States
- Van Andel Research Institute — Grand Rapids, United States (Active)
Researchers
- Principal investigator: Rothbart, Scott — Van Andel Research Institute
- Study coordinator: Rothbart, Scott
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.