Understanding how DNA changes affect the behavior of C. difficile bacteria
Epigenetic regulation of sporulation in Clostridioides difficile
['FUNDING_R21'] · TUFTS UNIVERSITY BOSTON · NIH-11139081
This study is looking at how changes in DNA affect the behavior of Clostridioides difficile, a germ that can cause serious infections in hospitals, to find new ways to treat these infections.
Quick facts
| Phase | ['FUNDING_R21'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | TUFTS UNIVERSITY BOSTON (nih funded) |
| Locations | 1 site (BOSTON, UNITED STATES) |
| Trial ID | NIH-11139081 on ClinicalTrials.gov |
What this research studies
This research investigates the role of DNA methylation in the behavior of Clostridioides difficile, a significant cause of hospital infections. By focusing on a specific enzyme, CamA, which is crucial for the bacteria's ability to form spores and persist in the environment, the study aims to uncover new therapeutic targets. The approach involves analyzing how changes in DNA affect the bacteria's physiology, which could lead to innovative treatments for infections caused by this pathogen.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have experienced recurrent or severe C. difficile infections.
Not a fit: Patients who do not have C. difficile infections or are not at risk for such infections may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of new therapies to effectively treat C. difficile infections.
How similar studies have performed: Previous research has shown promise in targeting bacterial physiology through genetic modifications, indicating potential for success in this novel approach.
Where this research is happening
BOSTON, UNITED STATES
- TUFTS UNIVERSITY BOSTON — BOSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SHEN, AIMEE — TUFTS UNIVERSITY BOSTON
- Study coordinator: SHEN, AIMEE
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.