Understanding how DNA changes affect suicide risk in bipolar disorder
Deciphering the role of neuronal and peripheral DNA methylation in suicide and bipolar disorder
This study is looking at how certain changes in DNA might help us understand why some people with bipolar disorder are at a higher risk of suicide, using brain samples from those who have passed away to find clues that could help identify others who might be struggling.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas Hlth Sci Ctr Houston NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project ID | NIH-10646479 on NIH RePORTER |
What this research studies
This research investigates the relationship between DNA methylation and the risk of suicide in individuals with bipolar disorder. By analyzing post-mortem brain tissues, the study aims to identify specific DNA changes that may indicate a higher vulnerability to suicidal behavior. The researchers will use advanced techniques to characterize these changes and validate potential biomarkers that could help identify patients at risk. This work seeks to deepen our understanding of the biological mechanisms underlying suicide in bipolar disorder.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults diagnosed with bipolar disorder, particularly those who have experienced suicidal thoughts or behaviors.
Not a fit: Patients without a diagnosis of bipolar disorder or those who have not experienced suicidal thoughts or behaviors may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new biomarkers for identifying individuals at high risk for suicide, enabling earlier intervention and prevention strategies.
How similar studies have performed: Previous research has shown promising results in identifying genetic and epigenetic markers associated with suicide risk, suggesting that this approach may yield valuable insights.
Where this research is happening
Houston, United States
- University of Texas Hlth Sci Ctr Houston — Houston, United States (Active)
Researchers
- Principal investigator: Fries, Gabriel Rodrigo — University of Texas Hlth Sci Ctr Houston
- Study coordinator: Fries, Gabriel Rodrigo
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.