Understanding how DNA changes affect immune function after sepsis
Official title: Analyzing the long-term effects of DNA methylation meditated immunosuppression following sepsis
Funded at Ohio State University · NIH-10923887 · Data updated 2026-11-12
This study is looking at how changes in your DNA after surviving sepsis can affect your immune system and overall health, with the hope of finding ways to help sepsis survivors feel better and stay healthier in the long run.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ohio State University NIH-funded |
| Lab location | 1 site (Columbus, UNITED STATES) |
| Project start | September 10, 2023 |
| Project end | July 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $393,750 |
| NIH project number | 5R35GM150968-02 |
| Project ID | NIH-10923887 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who have survived sepsis and are experiencing ongoing health issues related to their immune system.
✕Less likely to help
Patients who have not experienced sepsis or those with pre-existing immune disorders may not benefit from this research.
What this research studies
This research investigates the long-term effects of DNA methylation on immune function in patients who have survived sepsis. It aims to understand how changes in DNA can lead to immunosuppression, resulting in higher risks of infections, functional decline, and psychological issues. The study will analyze the activity of DNA methyltransferases and their role in gene silencing during and after sepsis. By integrating various research efforts, the goal is to improve the overall health outcomes for sepsis survivors.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments and support for sepsis survivors, enhancing their immune function and overall quality of life.
How similar studies have gone: While there has been some fragmented research in this area, this approach aims to unify and expand upon previous findings, making it a novel investigation.
Where this research is happening
-
Ohio State University
Columbus, United States Active
Researchers
- Principal investigator: Wisler, Jon R — Ohio State University
- Study coordinator: Wisler, Jon R
Related research
Other NIH-funded projects on the same topics.
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Understanding how DNA methylation affects immune recovery after sepsis
Researchers are studying how epigenetic changes after sepsis can weaken the immune system and affect long-term health in survivors.
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Sepsis-related DNA changes that may cause long-term immune weakness
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-
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This study tests whether adding hydrocortisone and stronger antibiotics can improve survival for adults with sepsis who also have AIDS or advanced immune suppression in regions with high TB.
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Coordinating ARDS, Pneumonia, and Sepsis research to improve care
A national coordinating center helps researchers studying ARDS and related infections work together more efficiently to learn what helps patients recover.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.