Understanding how DNA changes affect immune function after sepsis
Analyzing the long-term effects of DNA methylation meditated immunosuppression following sepsis
['FUNDING_OTHER'] · OHIO STATE UNIVERSITY · NIH-10923887
This study is looking at how changes in your DNA after surviving sepsis can affect your immune system and overall health, with the hope of finding ways to help sepsis survivors feel better and stay healthier in the long run.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | OHIO STATE UNIVERSITY (nih funded) |
| Locations | 1 site (Columbus, UNITED STATES) |
| Trial ID | NIH-10923887 on ClinicalTrials.gov |
What this research studies
This research investigates the long-term effects of DNA methylation on immune function in patients who have survived sepsis. It aims to understand how changes in DNA can lead to immunosuppression, resulting in higher risks of infections, functional decline, and psychological issues. The study will analyze the activity of DNA methyltransferases and their role in gene silencing during and after sepsis. By integrating various research efforts, the goal is to improve the overall health outcomes for sepsis survivors.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have survived sepsis and are experiencing ongoing health issues related to their immune system.
Not a fit: Patients who have not experienced sepsis or those with pre-existing immune disorders may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments and support for sepsis survivors, enhancing their immune function and overall quality of life.
How similar studies have performed: While there has been some fragmented research in this area, this approach aims to unify and expand upon previous findings, making it a novel investigation.
Where this research is happening
Columbus, UNITED STATES
- OHIO STATE UNIVERSITY — Columbus, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: WISLER, JON R — OHIO STATE UNIVERSITY
- Study coordinator: WISLER, JON R
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Disease