Understanding how DNA changes affect human traits
Decoding genome function with DNA methylation and human phenome data
This work aims to understand how changes in DNA, specifically DNA methylation, influence our cells and contribute to different human characteristics and health conditions.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Vanderbilt University NIH-funded |
| Lab location | 1 site (Nashville, UNITED STATES) |
| Project ID | NIH-11097288 on NIH RePORTER |
What this research studies
Our bodies have a complex instruction book called the genome, and DNA methylation acts like tiny markers on this book, telling our cells which parts to read and which to ignore. We are looking at specific 'hypomethylated regions' (HMRs) in DNA that are important for how cells develop and function. By comparing these HMR patterns across different cell types and linking them to human health information, we hope to uncover how genetic variations lead to specific traits or diseases. This helps us connect the detailed instructions in our DNA to what we see in people's health.
Who could benefit from this research
Good fit: This foundational research does not directly involve patient participation but could benefit individuals with conditions linked to genetic variations and cell function.
Not a fit: Patients seeking immediate new treatments or direct clinical intervention would not receive benefit from this basic science project.
Why it matters
Potential benefit: If successful, this work could lead to a better understanding of how genetic changes cause diseases, potentially opening doors for new ways to diagnose or treat them.
How similar studies have performed: Our lab's previous work has shown that HMR patterns can predict cellular characteristics and are linked to clinical traits, suggesting this approach is promising.
Where this research is happening
Nashville, UNITED STATES
- Vanderbilt University — Nashville, United States (Active)
Researchers
- Principal investigator: Hodges, Emily — Vanderbilt University
- Study coordinator: Hodges, Emily
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.