Understanding how DNA changes affect cell development and birth defects
Regulation of DNA methylation by TETs and QSER1
['FUNDING_R01'] · WEILL MEDICAL COLL OF CORNELL UNIV · NIH-10898762
This study is looking at how certain enzymes help control DNA changes during the early stages of development in zebrafish and human cells, which could help us understand why some birth defects happen.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | WEILL MEDICAL COLL OF CORNELL UNIV (nih funded) |
| Locations | 1 site (NEW YORK, UNITED STATES) |
| Trial ID | NIH-10898762 on ClinicalTrials.gov |
What this research studies
This research investigates the mechanisms by which specific enzymes regulate DNA methylation during early embryonic development. By studying zebrafish and human embryonic stem cells, the project aims to uncover how these processes influence cell fate and contribute to structural birth defects. The researchers utilize advanced techniques such as CRISPR screening to identify proteins that interact with DNA and affect gene expression. This work could lead to a better understanding of the genetic factors involved in normal and abnormal development.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with a family history of structural birth defects or those interested in the genetic basis of developmental disorders.
Not a fit: Patients with conditions unrelated to genetic or developmental issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could provide insights into preventing or treating birth defects by targeting the underlying genetic mechanisms.
How similar studies have performed: Previous research has shown success in understanding DNA methylation and its role in development, suggesting that this approach could yield valuable insights.
Where this research is happening
NEW YORK, UNITED STATES
- WEILL MEDICAL COLL OF CORNELL UNIV — NEW YORK, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: EVANS, TODD R — WEILL MEDICAL COLL OF CORNELL UNIV
- Study coordinator: EVANS, TODD R
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.