Understanding how DNA changes affect cancer treatment responses
Quantitative regulatory genomics: networks, cis-regulatory codes, and phenotypic variation
This study is looking at how differences in our DNA can affect how well breast cancer treatments work for different people, with the goal of creating more personalized treatment plans that fit each person's unique genetic makeup.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Georgia Institute of Technology NIH-funded |
| Lab location | 1 site (Atlanta, United States) |
| Project ID | NIH-10690568 on NIH RePORTER |
What this research studies
This research investigates how variations in DNA sequences influence the way patients respond to cancer treatments, particularly focusing on breast cancer. By developing advanced models to analyze gene regulatory mechanisms, the research aims to uncover why some individuals experience different outcomes from the same therapies. The approach combines biophysical modeling and statistical analysis of gene interactions, utilizing various biological data to enhance our understanding of cancer biology. This could lead to more personalized treatment strategies based on individual genetic profiles.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with breast cancer who may benefit from tailored therapeutic approaches based on their genetic makeup.
Not a fit: Patients with cancers unrelated to the mechanisms being studied or those who do not have genetic variations relevant to the research may not benefit.
Why it matters
Potential benefit: If successful, this research could lead to more effective and personalized cancer treatments for patients.
How similar studies have performed: Other research has shown promise in using genetic insights to improve cancer treatment outcomes, indicating that this approach has potential for success.
Where this research is happening
Atlanta, United States
- Georgia Institute of Technology — Atlanta, United States (Active)
Researchers
- Principal investigator: Sinha, Saurabh — Georgia Institute of Technology
- Study coordinator: Sinha, Saurabh
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.