Understanding how DNA building blocks affect our body's defense system
Deciphering the Role of dNTP Metabolism in Innate Immunity
['FUNDING_OTHER'] · UT SOUTHWESTERN MEDICAL CENTER · NIH-11139473
This project explores how the building blocks of DNA, called dNTPs, influence our body's natural defense system, especially in conditions like Alzheimer's disease.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UT SOUTHWESTERN MEDICAL CENTER (nih funded) |
| Locations | 1 site (DALLAS, UNITED STATES) |
| Trial ID | NIH-11139473 on ClinicalTrials.gov |
What this research studies
Our bodies rely on a balanced supply of DNA building blocks, called dNTPs, to keep our cells healthy and repair damage. When this balance is off, it can lead to cell damage and problems with our body's natural defense system, known as innate immunity. This research looks at how dNTPs affect a key part of our immune response called the NLRP3 inflammasome, which is involved in inflammation and tissue damage. By understanding this connection, we hope to learn more about how our immune system works, particularly when it's activated by things other than infections.
Who could benefit from this research
Good fit: Patients with conditions involving chronic inflammation or immune system dysfunction, such as Alzheimer's disease, could potentially benefit from future treatments developed from this foundational knowledge.
Not a fit: Patients without conditions related to inflammation or immune system dysfunction are unlikely to directly benefit from this specific basic science research.
Why it matters
Potential benefit: Successfully understanding this process could lead to new ways to manage inflammation and related conditions, including Alzheimer's disease.
How similar studies have performed: This research explores a relatively new area, as little is currently known about the specific role of dNTP metabolism in non-pathogen-induced innate immunity.
Where this research is happening
DALLAS, UNITED STATES
- UT SOUTHWESTERN MEDICAL CENTER — DALLAS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: ZHONG, ZHENYU — UT SOUTHWESTERN MEDICAL CENTER
- Study coordinator: ZHONG, ZHENYU
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Alzheimer disease dementia, Alzheimer syndrome, Alzheimer's Disease