Understanding how DNA breaks during the formation of sperm and eggs affects genetic health.
Germline mutagenesis at meiotic double-strand breaks
This study looks at how sperm and eggs are made in mammals and focuses on understanding how DNA breaks happen and are fixed during this process, which could help us learn more about genetic risks that affect reproductive health and the quality of eggs and sperm as we age.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Sloan-Kettering Inst Can Research NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-11084463 on NIH RePORTER |
What this research studies
This research investigates the process of meiotic recombination, which is crucial for the formation of sperm and eggs in mammals. It focuses on how DNA double-strand breaks (DSBs) are created and repaired during this process, particularly the role of the ATM kinase in regulating these breaks. By examining the consequences of improper repair, the study aims to uncover how these genetic events can lead to mutations that may impact human health and evolution. Patients may benefit from insights into genetic risks associated with reproductive health and age-related effects on gamete quality.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals undergoing fertility assessments or those with a family history of genetic disorders.
Not a fit: Patients who are not seeking to conceive or who do not have concerns about genetic health may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to a better understanding of genetic risks in reproduction, potentially improving fertility treatments and genetic counseling.
How similar studies have performed: Previous research has shown success in understanding DNA repair mechanisms, but this specific focus on meiotic DSBs and their implications for germline mutagenesis is relatively novel.
Where this research is happening
New York, United States
- Sloan-Kettering Inst Can Research — New York, United States (Active)
Researchers
- Principal investigator: Jasin, Maria — Sloan-Kettering Inst Can Research
- Study coordinator: Jasin, Maria
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.