Understanding how DNA breaks are repaired in human cells
DNA end processing by the Mre11/Rad50/Nbs1 complex in human cells
This study is looking at how our cells fix serious DNA damage, which can cause health problems, by focusing on a specific group of proteins that help with the repair process, and it aims to find out how these proteins work together to choose the best way to fix the DNA.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas at Austin NIH-funded |
| Lab location | 1 site (Austin, United States) |
| Project ID | NIH-10814798 on NIH RePORTER |
What this research studies
This research investigates the mechanisms by which human cells repair double-strand breaks in DNA, a critical type of damage that can lead to serious genetic issues. The study focuses on the Mre11/Rad50/Nbs1 complex and its role in processing DNA ends during repair, particularly how it interacts with other repair pathways. By using advanced biochemical techniques and single-molecule experiments, the researchers aim to clarify the sequence of events that dictate whether a cell uses non-homologous end joining or homologous recombination for DNA repair. This understanding could lead to improved strategies for addressing DNA damage in various diseases.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with genetic disorders or cancers associated with DNA repair deficiencies.
Not a fit: Patients without any known genetic predispositions to DNA repair issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better treatments for conditions related to DNA damage, such as cancer.
How similar studies have performed: Previous research has shown promising results in understanding DNA repair mechanisms, suggesting that this approach could yield valuable insights.
Where this research is happening
Austin, United States
- University of Texas at Austin — Austin, United States (Active)
Researchers
- Principal investigator: Paull, Tanya T — University of Texas at Austin
- Study coordinator: Paull, Tanya T
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.