Understanding how DNA and specific enzymes interact in kidney disease.
The crosstalk of DNA and lysine methyltransferases in ADPKD.
['FUNDING_R01'] · MAYO CLINIC ROCHESTER · NIH-10896328
This study is looking at how changes in DNA might affect the severity of Autosomal Dominant Polycystic Kidney Disease (ADPKD) in people who have the same genetic mutations, hoping to find new ways to understand and treat the condition.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | MAYO CLINIC ROCHESTER (nih funded) |
| Locations | 1 site (ROCHESTER, UNITED STATES) |
| Trial ID | NIH-10896328 on ClinicalTrials.gov |
What this research studies
This research investigates the role of DNA methylation and lysine methyltransferases in Autosomal Dominant Polycystic Kidney Disease (ADPKD). It aims to uncover how epigenetic changes can influence the severity of the disease, even among individuals with the same genetic mutations. By analyzing kidney tissue samples through advanced sequencing techniques, the study seeks to identify abnormal DNA methylation patterns that may contribute to cyst formation. This could lead to new insights into the mechanisms of ADPKD and potential therapeutic targets.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Autosomal Dominant Polycystic Kidney Disease, particularly those with varying disease severity.
Not a fit: Patients without a diagnosis of ADPKD or those with other unrelated kidney conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatment strategies that target the underlying epigenetic mechanisms of ADPKD.
How similar studies have performed: Previous research has shown promising results in understanding the role of epigenetics in various diseases, suggesting that this approach could yield valuable insights for ADPKD as well.
Where this research is happening
ROCHESTER, UNITED STATES
- MAYO CLINIC ROCHESTER — ROCHESTER, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: LI, XIAOGANG — MAYO CLINIC ROCHESTER
- Study coordinator: LI, XIAOGANG
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Adult Polycystic Kidney Disease, Autosomal Dominant Polycystic Kidney Disease