Understanding how DNA and histone proteins interact to regulate gene activity
Official title: Dynamics of DNA-histone interactions
Funded at Pennsylvania State University, the · NIH-10891342 · Data updated 2026-11-12
This study looks at how DNA and histone proteins work together to control gene activity, which is important for our health, and aims to find out how changes in these molecules can lead to issues like developmental disorders and cancer, with the hope of discovering new ways to diagnose and treat these conditions.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Pennsylvania State University, the NIH-funded |
| Lab location | 1 site (University Park, United States) |
| Project start | August 1, 2023 |
| Project end | July 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $587,804 |
| NIH project number | 5R35GM148208-02 |
| Project ID | NIH-10891342 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with genetic disorders or cancers that may be influenced by gene regulation mechanisms.
✕Less likely to help
Patients with conditions unrelated to genetic regulation or those not affected by DNA-histone interactions may not benefit from this research.
What this research studies
This research investigates the dynamic interactions between DNA and histone proteins within the nucleosome, which is crucial for gene regulation. By utilizing advanced single-molecule fluorescence techniques, the study aims to uncover how various modifications to DNA and histones affect gene accessibility and expression. The research focuses on understanding the complex mechanisms that can lead to developmental disorders and diseases, including cancer, when gene regulation goes awry. Patients may benefit from insights gained into these fundamental processes, potentially leading to new diagnostic and therapeutic strategies.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for genetic disorders and cancers linked to faulty gene regulation.
How similar studies have gone: Previous research has shown promising results in understanding gene regulation through similar molecular approaches, indicating potential for success in this area.
Where this research is happening
-
Pennsylvania State University, the
University Park, United States Active
Researchers
- Principal investigator: Lee, Tae-Hee — Pennsylvania State University, the
- Study coordinator: Lee, Tae-Hee
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.