Understanding how DNA affects heart health and aging
Official title: Cytosolic DNA is the Link Between Genomic Instability and Cardiovascular Aging
Funded at University of Texas Hlth Sci Ctr Houston · NIH-11052584 · Data updated 2026-11-12
This study is looking at how changes in a specific gene, called LMNA, might cause heart problems as we age, especially in people with certain genetic conditions, and it uses both human heart samples and mice to understand how this gene affects heart health over time.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas Hlth Sci Ctr Houston NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project start | August 15, 2023 |
| Project end | April 30, 2028 |
| Funding year | 2025 |
| Award (this year) | $575,947 |
| NIH project number | 5R01AG082751-03 |
| Project ID | NIH-11052584 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with known mutations in the LMNA gene or those experiencing symptoms of premature aging and cardiovascular issues.
✕Less likely to help
Patients without genetic predispositions to laminopathies or those not experiencing age-related cardiovascular conditions may not benefit from this research.
What this research studies
This research investigates the connection between genomic instability and cardiovascular aging, particularly focusing on the LMNA gene, which is crucial for maintaining the structure of the cell nucleus. By examining how mutations in this gene lead to premature aging syndromes and cardiovascular issues, the study aims to uncover the underlying mechanisms that contribute to heart disease in aging populations. The research employs both human heart samples and mouse models to explore the role of cytosolic DNA and its impact on heart function and aging processes.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating cardiovascular diseases associated with aging.
How similar studies have gone: Previous research has shown promising results in understanding the role of genomic instability in aging and cardiovascular health, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of Texas Hlth Sci Ctr Houston
Houston, United States Active
Researchers
- Principal investigator: Marian, Ali J — University of Texas Hlth Sci Ctr Houston
- Study coordinator: Marian, Ali J
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.